Genetic Testing for Spine Patients
Dr. Anthony Leone is one of the only doctors in Western New York who offers genetic testing for spine patients. This test is called the DMEx Genotype Panel, and it is imperative in determining a treatment that is truly custom built - specifically for you. A quick one step system is all you need to prevent using the wrong prescriptions or diagnosis.Sign-Up For Testing
Optimizing Medication Effectiveness
Experts have reported that around $300 billion is annually wasted on drugs which do not function properly in patients with certain genetic makeup. These people never receive the full benefit from these drugs. Meanwhile, other patients are showing dangerous side effects. Often times, a doctor may have to try several different medications on a patient before finding the medication that works the best.
Learn More About Genetic Testing
- What Patients Should Be Tested?
- The DME Panel - Improved Treatment Decisions
- The importance of Knowing a Patient's Genotype
- Making Informed Treatment Decisions
- What are adverse drug reactions?
What Patients Should Be Tested?
All patients can benefit from the DME Panel. Medications, even when prescribed by a doctor, can have adverse effects. The benefits of genetic testing are vast, and will give you the peace of mind - now and in the future - that you are taking the medications specific for your particular genetic makeup.
The DME Panel – Improved Treatment Decisions for Patients
In every step of drug metabolism, genetic variations play a role. The DME Genotype Panel assists in revealing variations and allowing personalized prescribing. The benefits include:
- Improved dosage estimates to personalize treatment
- Peace of mind in prescribing dosages
- Reduced risk from ADRs
- Improved clinical outcomes resulting from improved drug efficacy
The Importance of Knowing a Patient’s DME Genotype
Gene variations can affect the function of one or more drug metabolizing enzymes (DMEs) - many patients can exhibit this. These variations affect the cytochrome P450 enzymes. Drug metabolizing rate can be transformed by this altered enzyme function. Therefore, patients exhibiting these gene variations are more susceptible to toxicity or lack of drug efficacy. These variants define patients as poor or intermediate metabolizers. Multiple medications can increase the likelihood that one or more will be metabolized incorrectly. Because of this, patients who are on multiple drugs are at the highest risk for ADRs.
Making Informed Treatment Decisions for Patients
The liver is primarily in charge of metabolizing a vast majority of drugs. The p450 cytochrome family of enzymes includes CYP2C9, CYP2C18, CYP2D6, CYP3A4 and CYP1A2. This is the liver's primary mechanism for drug metabolizing. While there are standardized doses - all patients respond differently. Therefore, it is important to have a simply genetic test completed. This test looks at liver enzymes and will not only determine a patient's drug sensitivity, but will also provide them with a lifetime of protection against drug toxicity.
What are Adverse Drug Reactions?
Adverse drug reactions (ADRs) are injuries caused from medication, and are responsible for about 7,000 outpatient deaths every year. Thanks to genetic testing, ADRs are now preventable.
Sign-Up for Genetic Testing
To get set up with your genetic test, please contact us by using the "Send a Message" button below, or by calling 66-SPINE.